Designer Molecule Tackles Skin Cancer from Two Sides

blogger templates
By playing it safe and using a two-pronged attack, a novel designer molecule fights malignant melanoma. It was created and tested by an international team of researchers led by the University of Bonn. On the one hand, the substance is similar to components of viruses and in this way alerts the immune system. The body's own defences are also strengthened against cancer cells in this process. At the same time, the novel molecule also puts pressure on the tumour in a different way. It switches off a specific gene in the malignant cells, thus driving them to suicide. With mice suffering from cancer, the researchers have thus been able to fight metastases in the lung. In Nature Medicine's November issue they report about this promising strategy.

For their research project, the scientists drew on the latest insights into biology's box of tricks. A close relative of the nuclear DNA, known as RNA, served them as therapy. It has only been known for a few years that small RNA molecules can basically be used to target certain genes and switch them off. This effect is called RNA interference; the Americans Craig Mellow and Andrew Fire were awarded the Nobel Prize in 2006 for its discovery.

'We used this method in order to drive the tumour cells to suicide,' the Bonn dermatology researcher Professor Thomas Tüting explains. Every single body cell is equipped with a corresponding suicide programme. It is activated, for example, if the cell becomes malignant. It dies before it can do any more harm. 'But in tumours a gene is active that suppresses this suicide programme,' Professor Tüting, who is head of the Experimental Dermatology Laboratory, explains. 'We have pinpointed this gene and switched it off by using RNA interference.'

At the same time the researchers also crept up on cancer by another route: 'We basically "disguised" our RNA,? Professor Gunther Hartmann, director of the Institute of Clinical Chemistry and Pharmacology says. 'That is why the immune system took it for the genetic makeup of a virus.' Many viruses actually do use RNA to store information. So if the body discovers RNA fragments which it takes to be the genetic makeup of a virus, it mounts an attack on them. By means of this trick the body?s defences were prompted to tackle the tumour cells far more aggressively than normal.

Release date: November 2, 2008

Source: University of Bonn

0 Response to "Designer Molecule Tackles Skin Cancer from Two Sides"

Post a Comment

Labels

kesehatan Istilah Penyakit health ASKEP KESEHATAN artikel kesehatan A FARMASI ASKEP H KEPERAWATAN tips sehat penyakit M P S Tanaman Obat Indonesia G T D TIPS E info sehat tanaman obat C Menstruasi pengobatan alternatif B Berita Kesehatan K O wanita dan kesehatan CANCER Healthy Living I Weght Loss Diet dan Kesehatan Fat loss NURSING Obat Tradisional PENGOBATAN V olah raga Health and Fitness Illusion NUTRITION Tips Diet Sehat U alternative herbal gaya hidup sehat kesehatan jantung langsing mom and kids Asthma F Health today Hypertension Khasiat Daun Salam Kolera L R Tentang Kanker Yoga dan Kecantikan business nutrisi dan kesehatan pesan untuk pembaca AIDS - Acquired Immune Deficiency Abortus Abortus imminen Acut Miocard Infark Agnosia Alergi Alergi Obat Alpokat Alzheimer's Disease Amenorrhea Amnesia Disosiatif Anemia Angina Pectoris Angina Pektoris Angiofibroma Anorexia Nervosa Anosmia Anxietas Appendicitis Appendiksitis Aritmia Asthma Bronkhiale Aterosklerosis Atrial Septal Defect Auditory Illusion BPH (Benigna Prostat Hipertropi) Batu Empedu Berkah Herbal Bipolar Disorder Bronchiectasis Bronkhitis Bronkiektasis Buah Sehat Buah-buahan CANCER THERAPY COPD (Chronic Obstructive Pulmonal Disease) Cemas Cepalgia Cephalgia Chest Pain Cholelitiasis Cholera Colon Carcinoma Cronical diseas DHF (Dengue Haemorhagic Fever) Daftar Isi Decompensasi Cordis Decubitus Delirium Depression Dermatitis Atopik Dermatitis Kontak Diabetes Mellitus Diare Dispepsia Ebola Efusi Pleura Empiema Encephalitis Endokarditis Endometriosis Epilepsi Eritroderma FISIOLOGI FRAKTUR Faringitis Fatigue Fibromialgia Flu Babi Gagal Ginjal Akut Gagal Ginjal Kronis Gagal Jantung Gangguan / Kelainan Menstruasi (Haid) Gastritis Gastritis - acute Gastroenteritis Gastroentritis Gigantisme Gizi Glomerulonephritis Gout Guillain Barre Syndrome H1N1 (swine) influenza HERNIA NUKLEUS PULPOSUS Halusinasi Hemofilia Hemoroid Hepatitis Herpes Simplex Hidronefrosis Hidrosefalus Hiperemesis Gravidarum Hiperparatiroidisme Hipertensi Hipoglikemia Hipoparatiroidisme Hisprung Hyperpyrexia Hypertiroid Hypokalemia Hypomenorrhea ISPA Infeksi Saluran Kemih Info Seks Inkontinensia Urine Insertio Velamentosa Kanker Kolon Kanker Mulut Rahim Kanker Payudara Kanker Serviks Ketoacidosis Diabetik Ketuban Pecah Dini (KPD) Khasiat Buah Jamblang Khasiat Tanaman Obat Sidaguri Kistoma Ovari Konstipasi Leptospirosis Low Back Pain (LBP) Malaria Mania Marasmus Mastoiditis Meningitis Menstruasi Praecox Migrain Mioma Uteri Mola Hidatidosa Morbili Myasthenia Gravis Myocarditis N NEWS Nyeri Dada Optical Illusion Osteoarthritis Osteomalacia Osteomalasia Osteoporosis Otitis Media Akut OMA Parkinson's Disease Penyakit Alzheimer Penyakit Jantung Koroner Penyakit Jantung Rematik Penyakit Parkinson Perikarditis Peritonitis Pharingitis Plasenta Previa Pneumonia Premenstrual Syndrome (PMS) Prolapsus Uteri Propolis Pseudomenorrea Reumatoid Artritis Rheumatic Heart Disease Ricky Soebagdja SISTEMMUSKULOSKELETAL Schizophrenia Servicitis Sifilis Sinusitis Sirosis Hepatis Skabies Skoliosis Solusio Plasenta Spondilitis TBC Stenosis Aorta Strok Non Hemoragik (SNH) Struma Syndrome Stevens Johnson TERAPI PENGOBATAN Tanaman Beracun Tetanus Tetanus Neonatorum Tinnitus Tonsilitis Trachoma Trikomoniasis Tuberculosis Tuberkulosis Paru Tumor Tulang Typhoid Typhus Uremia Urinary Tract Infection Urticaria Vaginitis Vertigo Vesikolithiasis Vomiting W Waham Yoga dan Kesehatan acne and pregnancy autisme bahaya plastik biologi blackberry cara memasak sehat garlic health skin care herbal medicine informasi jarak bali khasiat Daun Duduk khasiat bawang putih khasiat buah-buahan maag mayoclinic melamin pencernaan pilates promo produk shisha stomach syndrom today tips vcd kesehatan vcd yoga workout